秋田県脳血管研究センター

放射線医学研究部

はじめに 　

秋田県立脳血管研究センター放射線医学研究部／放射線科　ホームページへようこそ。1968年開設以来の研究と診療、現在の活動をまとめました。20世紀後半から21世紀にかけての時代は、Technologyの進歩によって、いままで想像するしかなかったものが目に見えるようになった時代といえます。アポロ11号から送られた月面の地平線のかなたに浮かぶ地球の映像は、現代に生きる人々の世界観を変え、Globalizationの礎となりました。 Technologyの進歩は、医学・医療にも大きな変革をもたらしましたが、放射線医学はその恩恵を最も享受した分野のひとつです。「見えること」は、「知ること」の第一歩です。

私どもは、脳卒中の研究と診療を目的に設立されたセンターの放射線科として、「脳卒中」を見えるようにすること、正しく知ること、知ったことを治療に役立てること、を営々と続けてきました。どうすれば、見えるようになるのだろう。どうすれば、もっと正確にみえるのだろう。見えるようになったことは、どんな意味を持つのだろう。ここに集った人たちの知的好奇心と野蛮なバイタリティが、30年間脈々と受け継がれ、今に到達したような気がします。

臨床研究　(Clinical Research)

1. 脳血管障害の画像診断 (Diagnostic Radiology and Nuclear Medicine)

1970年代の脳血管造影、1970年台後半から80年代のX線CT、80年代前半にはじまった PET、90年代のMR、脳核医学。ここで行なわれてきた研究は、脳卒中の画像診断の歴史そのものといえます。血管から脳組織へ、さらに脳組織の様々な componentsへ、侵襲的な検査から、患者さんにとってよりやさしい検査へ、視覚的な評価から定量的な評価へ、病態の診断から病因の診断へ、30年間の軌跡が物語っています。

K. Yamaguchi, K. Uemura, H. Takahashi, M. Kowada, T. Kutsuzawa: Intracerebral leakage of contrast medium in apoplexy. British J Radiol 44;689-691:1971

K. Yamaguchi, K. Uemura, H. Takahashi: An angiographic study of sequential changes in hypertensive intracerebral haemorrhage. British J Radiol 46;125-130:1973

K. Yamaguchi, H. Takahashi, K. Uemura, M. Kowada, H. Kawakami. Venous filling abnormalities observed in hypertensive intracerebral haemorrhage. Neuroradiol 5;102-106:1973

K. Uemura, K. Goto, K. Ishii, Z. Ito, R. Hen, H. Kawakami. Sequential changes of regional cerebral circulation in cerebral infarction. Neuroradiol 16;228-232:1978

T. Okudera, K. Uemura, K. Nakajima, et al. Primary pontine hemorrhage: Corelations of pathological features with postmortem microangiographic and vertebral angiographic studies. The Mount Sinai J Med 45;305-321:1978

K. Goto, K. Tagawa, K. Uemura, K. Ishii, S. Takahashi. Posterior cerebral artery occlusion: Clinical, computed tomographic, and angiographic correlation. Radiology 132;357-368:1979

K. Uemura. I. Kanno, Y. Miura, S. Miura, S. Tominaga. Tomographic study of regional cerebral blood flow in ischemic cerebrovascular disease by 81mKr intraarterial infusion and HEADTOME. J Comput Assisst Tomogr 6;677-682:1982

S. Takahashi, K. Goto, H. Fukasawa, Y. Kawata, K. Uemura, K. Suzuki. Computed tomography of cerebral infarction along the distribution of the basal perforating arteries. Part 1: Striate arterial group. Radiology 155;107-118:1985

S. Takahashi, K. Goto, H. Fukasawa, Y. Kawata, K. Uemura,K. Yaguchi. Computed tomography of cerebral infarction along the distribution of the basal perforating arteries. Part 2: Thalamic arterial group. Radiology 155;119-130:1985

N. Tomura, K. Uemura, A. Inugami, Fujita H, S. Higano, F. Shishido. Early CT findings in cerebral infarction: Obscuration of the lentiform nucleus. Radiology 168;463-467:1988

K. Uemura, F. Shishido, S. Higano, A. Inugami, I. Kanno, K. Takahashi, N. Yasui, K. Togawa. Positron emision tomography in patients with a primary intracerebral hematoma. Acta Radiolo (suppl) 369;426-428:1987

K. Uemura, S. Higano, F. Shishido, A. Inugami, T. Yamaguchi, M. Murakami, I. Kanno. Regional cerebral blood flow and metabolism in patients with chronic obstructive carotid disease. Acta Radiol (suppl) 369:429-431:1987

F. Shishido, K. Uemura, A. Inugami, T. Ogawa, T. Yamaguchi, I. Kanno, M. Murakami, K. Tagawa, N. Yasui. Remore effects in MCA rerritory ischemic infarction: A study of regional cerebral blood flow and oxygen metabolism using positron emission tomography. Radiation Med 5;36-41:1987

I. Kanno, K. Uemura, S. Higano, M. Murakami, H. Iida, S. Miura, F. Shishido, A. Inugami, I. Sayama. Oxygen extraction fraction at maximally vasodilated tissue in the ischemic brain estimated from the regional CO2 responsiveness measured by positron emission tomography. J Cereb Blood Flow Metab 8;227-235:1988

N. Tomura, A. Inugami, I. Kanno, S. Higano, H. Fujita, K. Tabata, F. Shishido, K. Uemura, T. Abe. Differentiation between cerebral embolism and thrombosis on sequential CT scans. J Comput Asist Tomogr 14;26-31:1990

E. Shimosegawa, A. Inugami, T. Okudera, J. Hatazawa, T. Ogawa, H. Fujita, H. Toyoshima, K. Uemura. Embolic cerebral infarction: MR finding in the first 3 hours after onset. AJR 160;1077-1082:1993

S. Higano, K. Uemura, F. Shishido, I. Kanno, N. Tomura, K. Sakamoto. Evaluation of critically perfused area in acute ischemic stroke for therapeutic reperfusion: a clinical PET study. Ann Nucl Med 7;167-171:1993

E. Shimosegawa, J. Hatazawa, A. Inugami, H. Fujita, T. Ogawa, Y. Aizawa, I. Kanno, T. Okudera, K. Uemura. Cerebral infarction within six hours of onset: Prediction of completed infarction with Technetium-99m-HMPAO SPECT. J Nucl Med 35;1097-1103:1994

T. Okudera, YP Huang, et al. Development of posterior fossa dural sinuses, emissary veins, and jugular bulb: Morphological and radiologic study. AJNR 15;1871-1883:1994

K. Ishii, I. Kanno, K. Uemura, J. Hatazawa, T. Okudera, A. Inugami, T. Ogawa, H. Fujita, E. Shimosegawa. Comparison of carbon dioxide responsiveness of cerebral blood flow between affected and unaffected sides with crossed cerebellar diaschisis. Stroke 25;826-830:1994

K. Noguchi, T. Ogawa, A. Inugami, H. Toyoshima, S. Sugawara, J. Hatazawa, H. Fujita, E. Shimosegawa, I. Kanno, T. Okudera, K. Uemura, N. Yasui. Acute subarachnoid hemorrhag: MR Imaging with fluid-attenuated inversion recovery pulse sequences. Radiology 196;773-777:1995

K. Noguchi, T. Ogawa, H. Seto, A. Inugami, H. Hadeishi, H. Fujita, J. Hatazawa, E. Shimosegawa, T. Okudera, K. Uemura. Subacute and chronic subarachnoid hemorrhag: Diagnosis with fluid-attenuated inversion recovery MR imaging. Radiology 203;7257-262:1995

J. Hatazawa, T. Satoh, E. Shimosegawa, T. Okudera, A. Inugami, T. Ogawa, H. Fujita, K. Noguchi, I. Kanno, S. Miura, M. Murakami, H. Iida, Y. Miura, K. Uemura. Evaluation of cerebral infarction with Iodine-123-iomazenil SPECT. J Nucl Med 36:2154-2161:1995

J. Hatazawa, E. Shimosegawa, T. Satoh, I. Kanno, K. Uemura. Central benzodiazepine receptor distribution after subcortical hemorrhage evaluated by means of [123I]iomazenil and SPECT. Stroke 26:2267-2271:1995

T. Ogawa, T. Okudera, K. Noguchi, N. Sasaki, A. Inugami, K. Uemura, N. Yasui. Cerebral aneurysms:evaluation with three-dimentional CT angiography. AJNR 17;447-454:1996

T. Ogawa, Y. Yoshida, T. Okudera, K. Noguchi, H. Kado, K. Uemura. Secondary thalamic degeneration after cerebral infarction in the middle cerebral artery distribution: evaluation with MR imaging. Radiology 204:255-262:1997

T. Ogawa, T. Okudera, A. Inugami, K. Noguchi, H. Kado, Y. Yoshida, K. Uemura. Degeneration of the ipsilateral substantia nigra after striatal infarction: evaluation with MR imaging. Radiology 204:847-85:1997

J. Hatazawa, H. Iida, E. Shimosegawa, T. Satoh, M. Murakami, Y. Miura. Regional cerebral blood flow measurement with iodine-123-IMP autoradiography: normal values, reproducibility and sensitivety to hypoperfusion. J Nucl Med 38;1102-1108:1997

J. Hatazawa, E. Shimosegawa, T. Satoh, H. Toyoshima, T. Okudera. Subcortical hypoperfusion associated with asymptomatic white matter lesions on magnetic resonance imaging. Stroke 28;1944-1947:1997

T. Okudera, YP Huang, A. Fukuzumi, Y. Nakamura, J. Hatazawa, K. Uemura. Micro-angiographic studies of the medullary venous system of the cerebral hemisphere. Neuropathology 19;93-111:1999

J. Hatazawa, E. Shimosegawa, H. Toyoshima, T. Okudear, Y. Miura. Cerebral blood volume in acute brain infarction. A combined study with dynamic susceptibility vontrast MRI and 99mTc-HM PAO-SPECT. Stroke 30;800-806:1999

T. Kinoshita, T. Okudera, H. Tamura, T. Ogawa, J. Hatazawa. Assessment of lacunar hemorrhage associated with hypertensive stroke by echo-planar gradient-echo T2*-weighted MRI. Stroke 31;1646-1650:2000

2. 正常・加齢性変化について　

脳血流量、酸素消費量、ブドウ糖消費量、アミノ酸の脳への取り込みについて、主にPETを用いた研究が行われました。高齢化先進県の秋田では、正常加齢、動脈硬化の危険因子に修飾される病的老化、痴呆の研究が増々重要になると考えられます。今後、当放射線医学研究部／放射線科の研究・診療の重点領域です。

H. Sasaki, I. Kanno, M. Murakami, F. Shishido, K. Uemura. Tomographic measurement of kinetic rate constants in the fluorodeoxyglucose model using dynamic positron emission tomography. J Cerebr Blood Flow Metab 6;447-454:1986

T. Yamaguchi, I. Kanno, K. Uemura, F. Shishido, A. Inugami, T. Ogawa, M. Murakami, K. Suzuki. Reduction in regional cerebral metabolic rate of oxygen during human aging. Stroke 17;1221-1228:1987

H. Ito, J. Hatazawa, M. Murakami, S. Miura, H. Iida, PM Bloomfield, I. Kanno, H. Fukuda, K. Uemura. Aging effect on neural amino acid transport at the blood-brain barrier measured with L-[2-18F]-fluorophenylalanine and PET. J Nucl Med 35;1232-1237:1995

3. 脳腫瘍　

代謝の面からみた脳腫瘍の悪性度、浸潤範囲、再発と放射線壊死の鑑別について、研究が行われました。この領域は、当センターで2001年9月から開始するガンマナイフ治療に大いに生かされます。

T. Ogawa, K. Uemura, F. Shishido, T. Yamaguchi, A. Inugami, M. Murakami, I. Kanno, H. Sasaki, T. Kato, K. Hirata, M. Kowada, K. Mineura, T. Yasuda. Changes of cerebral blood flow, and oxygen and glucose metabolism following radiochemotherapy of gliomas: a PET study. J Comput Assisst Tomogr 12;290-297:1988

T. Ogawa, I. Kanno, F. Shishido, A. Inugami, S. Higano, H. Fujita, M. Murakami, K. Uemura, N. Yasui, K. Mineura, M. Kowada. Clinical value of PET with 18F-fluorodeoxyglucose and L-methyl-11C-methionine for diagnosis of recurrent brain tumor and radiation injury. Acta Radiol 32;197-202:1991

T. Ogawa, F. Shishido, I. Kanno, A. Inugami, H. Fujita, M. Murakami, E. Shimosegawa, H. Ito, J. Hatazawa, T. Okudera, K. Uemura, N. Yasui, K. Mineura. Radiology 186;45-53:1993

T. Ogawa, J. Hatazawa, A. Inugami, M. Murakami, H. Fujita, E. Shimosegawa, K. Noguchi, T. Okudera, I. Kanno, K. Uemura, H. Hadeishi, T. Sasajima. Carbon-11-methionine PET evaluation of intracerebral hematoma: Distinguishing neoplastic from non-neoplastic hematoma. J Nucl Med 36;2175-2179:1995

T. Ogawa, A. Inugami, J. Hatazawa, I. Kanno, M. Murakami, N. Yasui, K. Mineura, K. Uemura. Clinical positron emission tomography for brain tumors: Comparison of fluorodeoxyglucose F18 and L-methyl-11C-methionine. Am J Neuroradiol 17:345-353:1996

T. Ogawa, S. Miura, M. Murakami, H. Iida, J. Hatazawa, A. Inugami, I. Kanno, N. Yasui, T. Sasajima, K. Uemura. Quantitative evaluation of neutral amino acid transport in cerebral gliomas using positron emission tomography and fluorine-18 fluorophenylalanine. Eur J Nucl Med 23;889-895:1996

4. 脳循環および脳機能 (Functional Imaging)

機能賦活・薬物負荷

I. Law, I. Kanno, H. Fujita, NA Lassen, S. Miura, K. Uemura. J Neurolinguistics 6;243-252:1991 K. Cheng, H. Fujita, I. Kanno, S. Miura, K. Tanaka. Human cortical regions activated by void-field visual motion. An H215O PET study. J Neurophyiol 74;413-427:1995

E. Shimosegawa, I. Kanno, J. Hatazawa, H. Fujita, H. Iida, S. Miura, M. Murakami, A. Inugami, H. Itoh, T. Okudera, K. Uemura. Photic stimulation study of changing arterial partial pressure level of carbon dioxide. J Cerb Blood Flow Metab 15;111-114:1995

J. Hatazawa, T. Sasajima, E. Shimosegawa, H. Fujita, T. Okudera, I. Kanno, K. Minuera, K. Uemura. Regional cerebral blood flow response in gray matter heterotopia during finger tapping: an activation study with positron emission tomography. AJNR 479-482:1996

J. Hatazawa, H. Toyoshima, E. Shimosegawa, S. Sugawara, I. Kanno, K. Uemura. Influence of arterial partial pressure of carbon dioxide on cerebral MRA in normal volunteers. J Comput Assist Tomogr 18;187-191:1994

H. Ito, T. Kinoshita, Y. Tamura, I. Yokoyama, H. Iida. Effect of intravenous dipyridamole on cerebral blood flow in humans : A PET study. Stroke 30;1616-1620:1999

 H. Ito, K. Takahashi, J. Hatazawa, SG Kim I. Kanno Changes in human regional cerebral blood flow and cerebral blood volume during visual stimulation measured by positron emission tomography. J Cereb Blood Flow Metab 21;608-612:2001

5. 症例報告 (Case reports)

T. Okudera, T. Chida, K. Uemura, K. Takita, K. Yamaguchi, Cryptic arteriovenous malformation in the pons: a case report. The mount Sinai J Med 45;86-91:1978

T. Abe, S. Higano, N. Tomura, A. Inugami, F. Shishido, K. Uemura. A saccular aneurysm arising from the fenestration of the basilar artery-a case report- The Kurume Med J 34;203-206:1987

S. Higano, F. Shishido, M. Nagashima, N. Tomura, M. Murakami, A. Inugami, H. Fujita, Tabata, N. Yasui, K. Uemura. PET evaluation of spinal cord tumor using 11C-methionine. J Comput Assist Tomogr 14;297-299:1990

N. Tomura, A. Inugami, K. Uemura, H. Hadeishi, N. Yasui. Multiple medullary venous malformations devreasing cerebral blood flow: case report. Surg Neurol 35;131-135:1991

T. Ogawa, T. Okudera, H. Fukasawa, M. Hashimoto, et al. Unusual widening of Virchow-Robin spaces: MR appearance. AJNR 16;1238-1242:1995

T. Ogawa, A. Inugami, H. Fujita, J. Hatazawa, E, Shimosegawa, I. Kanno, T. Okudera, K. Uemura, K. Nagata. AJNR 16;978-981:1995

E. Shimosegawa, J. Hatazawa, K. Nagata, T. Okudera, A. Inugami, T. Ogawa, H. Fujita, H. Itoh, I. Kanno, K. Uemura. Cerebral blood flow and glucose metabolism measurements in a patient surviving one year after carbon monoxide intoxication. J Nucl Med 33:1696-1698:1992

F. Shishido, K. Uemura, A. Inugami, N. Tomura, S. Higano, H. Fujita, H. Sasaki, I. Kanno, M. Murakami, Y. Watahiki, K. Nagata. Cerebral oxygen and glucose metabolism and blood flow in mitochondrial encephalopathy: a PET study. Neuroradiol 38;102-107:1996

K. Ishii, T. Ogawa, J. Hatazawa, I. Kanno, A. Inugami, H. Fujita, E. Shimosegawa, M. Murakami, T. Okudera, K. Uemura. High L-methyl-[11C]methionine uptake in brain abscess: a PET study. J Comput Assist Tomogr 17;660-661:1993

J. Hatazawa, H. Itou, E. Shimosegawa. I. Kanno, M. Murakami, S. Miura, H. Iida, T. Okudera, A. Inugami, T. Ogawa, H. Fujita, Y. Satoh, K. Nagata, Y. Hirata, K. Uemura. Accumulation of L-[2-(F-18)]fluorophenylalanine in peri-infarct area in a patient with acute cerebral infarction. Ann Nucl Med 8;213-217:1994

H. Kado, T. Ogawa, J. Hatazawa, M. Iwase, I. Kanno, T. Okudera, K. Uemura. AJNR 17;937-938:1996

H. Kado, T. Ogawa, T. Okudera, I. Kanno, J. Hatazawa, K. Uemura. Parapharyngeal meningioma extending from the intracranial space evaluated by FDG PET. J Nucl Med 39;302-304:1998

基礎研究（Basic Research）

(1) 測定装置 (Instrument)

I. Kanno, K. Uemura, S. Miura, Y. Miura. HEADTOME: a hybrid emission tomograph for single photon and positron emission imaging of the brain. J Comput Assist Tomogr 5;216-226:1981

I. Kanno, S. Miura, S. Yamamoto, H. Iida, M. Murakami, K. Takahashi, K. Uemura. Design and evaluation of a positron emission tomograph: HEADTOME III. J Comput Assist Tomogr 9;931-939:1985

H. Iida, S. Miura, I. Kanno, M. Murakami, K. Takahashi, K. Uemura, Y. Hirose, M. Amano, S. Yamamoto, K. Tanaka. Design and evaluation of HEADTOME-IV, A whole-body positron emission tomograph. IEEE Transactions on Nuclear Science 37;1006-1010:1989

H. Iida, S. Miura, I. Kanno, T. Ogawa, K. Uemura. A New PET Camera for noninvasive quantitation of physiological functional parametric images. HEADTOME-V-Dual. Quantification of brain function using PET (eds. R. Myers, V. Cunningham, D. Bailey, T. Jones) p57-61, Academic Press, London, 1996

(2) 測定法 (Measurement and Analytical methods)

I. Kanno, N.A. Lassen. Two methods for calculating regional cerebral blood flow from emission computed tomography of inert gas concentrations. J Comput Assist Tomogr 3;71-76:1979

I. Kanno, K. Uemua. Some experimental errors in calculating regional cerebral blood flow from the intracerebral 133Xe clearance curves:a quantitative evaluation employing a digital model. Stroke 6;370-375:1975

H. Iida, I. Kanno, S. Miura, M. Murakami, K. Takahashi, K. Uemura. Error analysis of a quantitative cerebral blood flow measurement using H215O autoradiography and positron emission tomography, with respect to the dispersion of the input function. J Cereb Blood Flow Metab 6:536-545:1986

I. Kanno, H. Iida, S. Miura, M. Murakami, K. Takahashi, H. Sasaki, A. Inugami, F. Shishido, K. Uemura. A system for cerebral blood flow measurement using an H215O auroradiographic method and positron emission tomography. J Cereb Blood Flow Metab 7;143-153:1987

I. Kanno, H. Iida, S. Miura, M. Murakami. Optimal scan time of oxygen-15-labeled water injection method for measurement of cerebral blood flow. J Nucl Med 32;1931-1934:1991

H. Iida, H. Itoh, M. Nakazawa, H. Hatazawa, Y. Ohnishi, K. Uemura. Quantitative mapping of regional cerebral blood flow using iodine-123-IMP and SPECT. J Nucl Med 35;2019-2030:1994

H. Iida. T. Jones, S. Miura. Modeling approach to eliminate the need to separate arterial plasma in oxygen-15 inhalation positron emission tomography. J Nucl Med 34;1333-1340:1993

H. Ito, H. Iida, PM Bloomfield, M. Murakami, A. Inugami, I. Kanno, H. Fukuda, K. Uemura. Rapid calculation of regional cerebral blood flow and distribution volume using iodine-123-iodoamphetamine and dynamic SPECT. J Nucl Med 36;531-536:1995

H. Iida, et al. A multicenter validation of regional cerebral blood flow quantitation using [123I]iodoamphetamine and singlephoton emission computed tomography. J Cereb Blood Flow Metab 16;781-793:1996

H. Iida, Y. Narita, H. Kado, A. Kashikura, S. Sugawara, Y. Shoji, T. Kinoshita, T. Ogawa, S. Eberl. Effects of scatter and attenuation correction on quantitative assessment of regional cerebral blood flow with SPECT. J Nucl Med 39:181-189:1998

H. Ito, H. Iida, T. Kinoshita, J. Hatazawa, T. Okudera, K. Uemura. Effects of scatter correction on regional distribution of cerebral blood flow using I-123-IMP and SPECT. ANM 13;331-336:1999

(3) 画像解析法 (Image analysis)

S. Miura, I. Kanno, H. Iida, M. Murakami, K. Takahashi, H. Sasaki, A. Inugami, F. Shishido, T. Ogawa, K. Uemura. Anatomocal adjustments in brain positron emission tomography using CT images. J Comput Assist Tomogr 12;363-367:1988

BA Ardekani, M. Braun, I. Kanno, BF Hutton. Automatic detection of intradural spaces in MR imaging. J Comput Assist Tomogr 18;963-969:1994

BA Ardekani, M. Braun, B Hutton, I. Kanno, K. Uemura. A fully automated multimodality image registration alhorithm. J Comput Assist Tomogr 19;615-623:1995

BA Ardekani, M Braun, B Hutton, I. Kanno, H. Iida. Minimum cross-entropy reconstruction of PET images using prior anatomical information. Phy Med Biol 41;2497-2517:1996

J. Kershaw, BA Ardekani, I. Kanno. Application of Baysian Inference to fMRI data analysis. IEEE Transactions on Medical Imaging. 18;1138-1153:1999

(4) 放射性薬剤（Radiopharmaceuticals-basic）

M. Murakami, S. Miura, I. Itoh, N. Gotoh, H. Nakamichi. Effects of nucleitides and nucleosides on the activity of cyclic AMP phosphodiesterase from the brain. Tohoku J Exp. Med 141;23-31:1983

K. Takahashi, M. Murakami, E. Hagami, H. Sasaki, Y. Kondo, S. Mizusawa, H. Nakamichi, H. Iida, S. Miura, I. Kanno, K. Uemura, T. Ido. Radiosynthesis of 15O-labeled butanol available for clinical use. J Label Comp Radiopharm 23;1111-1113:1986

M. Murakami, K. Takahashi, Y. Kondo, S. Mizusawa, H. Nakamichi, H. Sasaki, E. Hagami, H. Iida, I. Kanno, S. Miura, K. Uemura. The comparative synthesis of 18F-fluorophenylalanines by electrophilic substitution with 18F-F2 and 18F-AcOF. J Label Comp Radiopharm 25;573-578:1988

M. Murakami, K. Takahashi, Y. Kondo, S. Mizusawa, H. Nakamichi, H. Sasaki, E. Hagami, H. Iida, I. Kanno, S. Miura, K. Uemura. 2-18F-phenylalanine and 3-18F-tyrosine- synthesis and preliminary data of tracer kinetics. J Label Comp Radiopharm 25;773-782:1988

M. Murakami, K. Takahashi, Y. Kondo, S. Mizusawa, H. Nakamichi, H. Sasaki, E. Hagami, H. Iida, I. Kanno, S. Miura, K. Uemura. The slow metabolism of L-[2-18F]-fluorophenylalanine in rat. J Label Comp Radiopharm 27;245-255:1989

K. Takahashi, M. Murakami, E. Hagami, H. Sasaki, Y. Kondo, S. Mizusawa, H. Nakamichi, H. Iida, I. Kanno, K. Uemura. Radiosynthesis of 15O-labeled hydrogen peroxide. J Label Comp Radiopharm 27:1167-1175:1989

K. Takahashi, M. Murakami, S. Miura, H. Iida, I. Kanno, K. Uemura. Synthesis and autoradiographic localization of muscarinic cholinergic antagonist (+)N-[11C]methyl-3-piperidyl benzilate as a potent radioligand for positron emission tomography. Applied Radiation and Isotopes 50;521-525:1999

(5) 放射性薬剤（Radiopharmaceuticals-clinical）

A. Inugami, I. Kanno, K. Uemura, F. Shishido, M. Murakami, N. Tomura, H. Fujita, S. Higano. Linearization correction of 99mTc-labeled hexamethyl-propylene amine oxine (HM-PAO) image in terms of regional CBF distribution: comparison to C15O2 inhalation steady-state method measured by positron emission tomography. 8:S52-60:1988

F. Shishido, K. Uemura, M. Murakami, A. Inugami, T. Ogawa, H. Fujita, E. Shimosegawa, I. Kanno, Y. Aizawa, K. Nagata, Y. Ono. Cerebral uptake of 99mTc-bicisate in patients with cerebrovascular disease in comparison with CBF and CMRO2 measured by positron emission tomography. J Cereb Blood Flow Metab 14;S66-75:1994

 E. Shimosegawa, J. Hatazawa, Y. Aizawa, Y. Shoji, T. Hachiya, M. Murakami. Technetium-99m-ECD brain SPECT in misery perfusion. J Nucl Med 38:791-796:1997

放射線医学研究部／放射線科スタッフ

研究員

• 三浦修一　（研究局長） 
• 木下俊文　（研究部長）
• 木下富美子　（研究員）
• 篠原祐樹　（研究員）
• 茨木正信　（研究員）
• 中村和浩　（研究員）
• 工藤和彦　（研究員）

放射線科技師

• 豊嶋英仁（技師長）
• 菅原重喜
• 沢木昭光
• 佐藤郁
• 大村知巳
• 佐々木和子
• 小野円
• 武内洋子
• 太田麻純
• 小玉未央

画像診断センター 　

1997年9月に、放射線科内に画像診断センターを開設し、県内の医療機関から依頼された検査を行っています。CT、MR、 SPECT、PETによる中枢神経系、腫瘍性疾患の画像診断が中心です。開始当初は月間10～20例でしたが、途中の増減はあるものの、現在月間30～40例の依頼を受けています。